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TNK1 Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q13470 |
|---|
| Gene ID | 8711 |
|---|---|
| Other Names | Non-receptor tyrosine-protein kinase TNK1, CD38 negative kinase 1, TNK1 {ECO:0000312|EMBL:AAC994121} |
| Target/Specificity | The synthetic peptide sequence is selected from aa 554-568 of HUMAN TNK1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TNK1 {ECO:0000312|EMBL:AAC99412.1} |
|---|---|
| Function | Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. |
| Cellular Location | Cytoplasm. Membrane; Peripheral membrane protein |
| Tissue Location | Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.
References
Hoehn G.T.,et al.Oncogene 12:903-913(1996).
Hoehn G.T.,et al.Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
Felschow D.M.,et al.Biochem. Biophys. Res. Commun. 273:294-301(2000).
Olsen J.V.,et al.Cell 127:635-648(2006).
Hoare S.,et al.Cancer Res. 68:8723-8732(2008).
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