F2 Blocking Peptide (N-Term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P00734 |
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Gene ID | 2147 |
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Other Names | Prothrombin, Coagulation factor II, Activation peptide fragment 1, Activation peptide fragment 2, Thrombin light chain, Thrombin heavy chain, F2 |
Target/Specificity | The synthetic peptide sequence is selected from aa 46-59 of HUMAN F2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | F2 |
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Function | Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. |
Cellular Location | Secreted, extracellular space. |
Tissue Location | Expressed by the liver and secreted in plasma. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.
References
Degen S.J.F.,et al.Biochemistry 26:6165-6177(1987).
Wang W.,et al.Haemophilia 10:94-97(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Degen S.J.F.,et al.Biochemistry 22:2087-2097(1983).
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