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EPS15 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P42566
Other Accession NP_001972
Clone Names 3080406
Additional Information
Gene ID 2060
Other Names Epidermal growth factor receptor substrate 15, Protein Eps15, Protein AF-1p, EPS15, AF1P
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2159a was selected from the N-term region of human EPS15 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name EPS15
Synonyms AF1P
Function Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
Cellular Location Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit Note=Recruited to the plasma membrane upon EGFR activation and localizes to coated pits. Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and in cytoplasmic juxtanuclear structures called aggresomes
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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EPS15 is involved in cell growth regulation, possibly via the regulation of mitogenic signals and control of cell proliferation. EPS15 also participates in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Potential interaction partners include AP2A2, STN2, EPN1, and CRK via its SH3-binding sites. EPS15 is ubiquitously expressed. Phosphorylation on Tyr-849 is involved in the internalization of EGFR. EPS15 is not required for membrane translocation after EGF treatment or for targeting to coated pits, but essential for a subsequent step in EGFR endocytosis. This protein is involved in a t(1;11)(p32;q23) chromosomal translocation in acute leukemias causing fusion to the trithorax (MLL or HRX) gene product which contains DNA-binding motifs resulting in a rogue activator protein. Structurally, EPS15 contains 2 EF-hand calcium-binding domains, 3 EH domains, and 2 ubiquitin-interacting motif (UIM) repeats.


de Beer, T., et al., Nat. Struct. Biol. 7(11):1018-1022 (2000).Enmon, J.L., et al., Biochemistry 39(15):4309-4319 (2000).de Beer, T., et al., Science 281(5381):1357-1360 (1998).Chen, H., et al., Nature 394(6695):793-797 (1998).Matsuda, M., et al., J. Biol. Chem. 271(24):14468-14472 (1996).

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$ 277.78
Cat# BP2159a
Availability: 2 weeks
Bulk Size

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