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GCKR Blocking Peptide (N-Term)

Synthetic peptide

     
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Product Information
Primary Accession Q14397
Additional Information
Gene ID 2646
Other Names Glucokinase regulatory protein, GKRP, Glucokinase regulator, GCKR
Target/Specificity The synthetic peptide sequence is selected from aa 87-100 of HUMAN GCKR
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GCKR {ECO:0000303|PubMed:8589523, ECO:0000312|HGNC:HGNC:4196}
Function Regulates glucokinase (GCK) by forming an inactive complex with this enzyme (PubMed:23621087, PubMed:23733961). Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal (PubMed:10456334). The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (PubMed:23621087, PubMed:23733961).
Cellular Location Cytoplasm. Nucleus. Mitochondrion {ECO:0000250|UniProtKB:Q07071}. Note=Under low glucose concentrations, GCKR associates with GCK and the inactive complex is recruited to the hepatocyte nucleus.
Tissue Location Found in liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen.
Research Areas
Citations (0)

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Background

Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6- phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity.

References

Warner J.P.,et al.Mamm. Genome 6:532-536(1995).
Hayward B.E.,et al.Genomics 49:137-142(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
de la Iglesia N.,et al.FEBS Lett. 456:332-338(1999).

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$ 277.78
Cat# BP21610a
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