SLC24A4 Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8NFF2 |
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Gene ID | 123041 |
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Other Names | Sodium/potassium/calcium exchanger 4, Na(+)/K(+)/Ca(2+)-exchange protein 4, Solute carrier family 24 member 4, SLC24A4, NCKX4 |
Target/Specificity | The synthetic peptide sequence is selected from aa 364-378 of HUMAN SLC24A4 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SLC24A4 (HGNC:10978) |
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Function | Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (PubMed:12379639, PubMed:26631410). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived (By similarity). May play a role in calcium transport during amelogenesis (PubMed:23375655, PubMed:24621671). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Cytoplasm {ECO:0000250|UniProtKB:Q8CGQ8} |
Tissue Location | Expressed abundantly in all regions of the brain, aorta, lung and thymus (PubMed:12379639). Expressed at lower levels in the stomach and intestine (PubMed:12379639) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis (By similarity).
References
Li X.-F.,et al.J. Biol. Chem. 277:48410-48417(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Heilig R.,et al.Nature 421:601-607(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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