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UBCH9 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q969T4
Clone Names 3080811
Additional Information
Gene ID 10477
Other Names Ubiquitin-conjugating enzyme E2 E3, UbcH9, Ubiquitin carrier protein E3, Ubiquitin-conjugating enzyme E2-23 kDa, Ubiquitin-protein ligase E3, UBE2E3, UBCE4, UBCH9
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2170b was selected from the C-term region of human UBCH9 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBE2E3
Synonyms UBCE4, UBCH9
Function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest.
Cellular Location Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm in a IPO11-dependent manner
Tissue Location Ubiquitously expressed at low levels. Highly expressed in skeletal muscle.
Research Areas
Citations (0)
citation

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Background

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBCH9 is a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Two alternatively spliced transcript variants encoding the same protein have been found.

References

Ito, K., et al., Cytogenet. Cell Genet. 84 (1-2), 99-104 (1999).

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$ 277.78
Cat# BP2170b
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Availability: 2 weeks
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