|Other Names||UV excision repair protein RAD23 homolog A, HR23A, hHR23A, RAD23A|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2173b was selected from the C-term region of human RAD23A . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'- linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome.|
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Provided below are standard protocols that you may find useful for product applications.
RAD223A is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.
Mueller, T.D., et al., EMBO J. 22(18):4634-4645 (2003).Mueller, T.D., et al., J. Mol. Biol. 319(5):1243-1255 (2002).Elder, R.T., et al., Nucleic Acids Res. 30(2):581-591 (2002).Chen, L., et al., EMBO Rep. 2(10):933-938 (2001).Gaynor, E.M., et al., Exp. Cell Res. 267(2):243-257 (2001).
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