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TMEM97 Blocking Peptide (N-term)

Synthetic peptide

Product Information
Primary Accession Q5BJF2
Additional Information
Gene ID 27346
Other Names Transmembrane protein 97, Protein MAC30, TMEM97, MAC30
Target/Specificity The synthetic peptide sequence is selected from aa 42-56 of HUMAN TMEM97
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TMEM97 (HGNC:28106)
Function Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cancer cells (PubMed:28559337). Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation (PubMed:23922215, PubMed:25620095). Under investigation for its potential diagnostic and therapeutic uses (PubMed:23922215, PubMed:25620095). May play a role as a regulator of cellular cholesterol homeostasis (PubMed:19583955). May function as sterol isomerase (PubMed:25566323). May alter the activity of some cytochrome P450 proteins (PubMed:22292588).
Cellular Location Nucleus membrane; Multi-pass membrane protein. Rough endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localized at cell membrane and in lysosomes in sterol-depleted cells when expression of endogenous TMEM97 is stimulated.
Tissue Location Widely expressed in normal tissues. Expressed in pancreatic, renal, breast, colon, ovarian surface epithelial (OSE) cells. Highly expressed in various proliferating cancer cells (PubMed:23922215).
Research Areas
Citations (0)

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Plays a role as a regulator of cellular cholesterol homeostasis.


Murphy M.,et al.Cell Growth Differ. 4:715-722(1993).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Kayed H.,et al.Histol. Histopathol. 19:1021-1031(2004).
Wilcox C.B.,et al.BMC Cancer 7:223-223(2007).
Bartz F.,et al.Cell Metab. 10:63-75(2009).

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$ 277.78
Cat# BP21745a
Availability: 2 weeks
Bulk Size

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