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RAP2A Blocking Peptide (N-Term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P10114 |
|---|
| Gene ID | 5911 |
|---|---|
| Other Names | Ras-related protein Rap-2a, RbBP-30, RAP2A |
| Target/Specificity | The synthetic peptide sequence is selected from aa 26-38 of HUMAN RAP2A |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RAP2A (HGNC:9861) |
|---|---|
| Function | Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form (PubMed:14966141, PubMed:15342639, PubMed:16246175, PubMed:16540189, PubMed:18930710, PubMed:20159449, PubMed:35293963). In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK (PubMed:14966141, PubMed:15342639, PubMed:18930710, PubMed:20159449). Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development (PubMed:20159449). More generally, it is part of several signaling cascades and regulates cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading (PubMed:14966141, PubMed:15342639, PubMed:16246175, PubMed:16540189, PubMed:18930710, PubMed:20159449, PubMed:35293963). |
| Cellular Location | Midbody. Cell projection, lamellipodium membrane. Golgi apparatus. Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Lysosome. Note=Localized to the Golgi (PubMed:35293963, PubMed:7962206). May also localize to the gelatinase- containing granules of neutrophils (PubMed:8391995). Colocalized with RASGEF1B to midbody at telophase (PubMed:23894443). Localized predominantly to the plasma membrane, where it is enriched at lamellipodia ruffles (PubMed:35293963). Cycles between the lamellipodia plasma membrane and endosomes when ubiquitinated by the ECS(RAB40B) complex (PubMed:35293963). Without the ubiquitin signal, sorted to lysosomes for degradation (PubMed:35293963) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.
References
Pizon V.,et al.Oncogene 3:201-204(1988).
Fan Z.S.,et al.Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
Puhl H.L. III,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dunham A.,et al.Nature 428:522-528(2004).
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