CHRNA4 Blocking Peptide (C-Term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P43681 |
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Gene ID | 1137 |
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Other Names | Neuronal acetylcholine receptor subunit alpha-4, CHRNA4, NACRA4 |
Target/Specificity | The synthetic peptide sequence is selected from aa 492-503 of HUMAN CHRNA4 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CHRNA4 |
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Synonyms | NACRA4 |
Function | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions. |
Cellular Location | Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor |
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Provided below are standard protocols that you may find useful for product applications.
Background
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.
References
Monteggia L.M.,et al.Gene 155:189-193(1995).
Steinlein O.K.,et al.Genomics 32:289-294(1996).
Elliott K.J.,et al.J. Mol. Neurosci. 7:217-228(1996).
Groot Kormelink P.J.,et al.FEBS Lett. 400:309-314(1997).
Deloukas P.,et al.Nature 414:865-871(2001).
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