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ANO10 Blocking Peptide (C-Term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NW15 |
|---|
| Gene ID | 55129 |
|---|---|
| Other Names | Anoctamin-10, Transmembrane protein 16K, ANO10, TMEM16K |
| Target/Specificity | The synthetic peptide sequence is selected from aa 640-653 of HUMAN ANO10 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ANO10 |
|---|---|
| Synonyms | TMEM16K |
| Function | Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane |
| Tissue Location | Highly expressed in the brain. Intermediate levels in the retina and heart and low levels in the placenta, liver, lung, duodenum, kidney, testis and spleen. In brain areas, highest expression in the frontal and occipital cortices and in the cerebellum. Lower expression in the fetal brain than in the adult brain |
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Provided below are standard protocols that you may find useful for product applications.
Background
Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Schreiber R.,et al.J. Biol. Chem. 285:7838-7845(2010).
Duran C.,et al.Acta Pharmacol. Sin. 32:685-692(2011).
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