AAAS Blocking Peptide (C-Term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9NRG9 |
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Gene ID | 8086 |
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Other Names | Aladin, Adracalin, AAAS, ADRACALA |
Target/Specificity | The synthetic peptide sequence is selected from aa 415-425 of HUMAN AAAS |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | AAAS |
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Synonyms | ADRACALA |
Function | Plays a role in the normal development of the peripheral and central nervous system (PubMed:11062474, PubMed:11159947, PubMed:16022285). Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment (PubMed:26246606). |
Cellular Location | Nucleus, nuclear pore complex. Cytoplasm, cytoskeleton, spindle pole. Nucleus envelope. Note=In metaphase cells localizes within the spindle with some accumulation around spindle poles, with the highest concentration between the centrosome and metaphase plate (PubMed:26246606). The localization to the spindle is microtubule- mediated (PubMed:26246606). |
Tissue Location | Widely expressed (PubMed:11159947, PubMed:16022285). Particularly abundant in cerebellum, corpus callosum, adrenal gland, pituitary gland, gastrointestinal structures and fetal lung (PubMed:11159947). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Plays a role in the normal development of the peripheral and central nervous system.
References
Tullio-Pelet A.,et al.Nat. Genet. 26:332-335(2000).
Handschug K.,et al.Hum. Mol. Genet. 10:283-290(2001).
Li X.,et al.Mol. Biol. Rep. 32:127-131(2005).
Li Y.,et al.Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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