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AAAS Blocking Peptide (C-Term)

Synthetic peptide

     
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Product Information
Primary Accession Q9NRG9
Additional Information
Gene ID 8086
Other Names Aladin, Adracalin, AAAS, ADRACALA
Target/Specificity The synthetic peptide sequence is selected from aa 415-425 of HUMAN AAAS
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name AAAS
Synonyms ADRACALA
Function Plays a role in the normal development of the peripheral and central nervous system (PubMed:11062474, PubMed:11159947, PubMed:16022285). Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment (PubMed:26246606).
Cellular Location Nucleus, nuclear pore complex. Cytoplasm, cytoskeleton, spindle pole. Nucleus envelope. Note=In metaphase cells localizes within the spindle with some accumulation around spindle poles, with the highest concentration between the centrosome and metaphase plate (PubMed:26246606). The localization to the spindle is microtubule- mediated (PubMed:26246606).
Tissue Location Widely expressed (PubMed:11159947, PubMed:16022285). Particularly abundant in cerebellum, corpus callosum, adrenal gland, pituitary gland, gastrointestinal structures and fetal lung (PubMed:11159947).
Research Areas
Citations (0)

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Background

Plays a role in the normal development of the peripheral and central nervous system.

References

Tullio-Pelet A.,et al.Nat. Genet. 26:332-335(2000).
Handschug K.,et al.Hum. Mol. Genet. 10:283-290(2001).
Li X.,et al.Mol. Biol. Rep. 32:127-131(2005).
Li Y.,et al.Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 277.78
Cat# BP21984b
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