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MRI1 Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BV20 |
|---|
| Gene ID | 84245 |
|---|---|
| Other Names | Methylthioribose-1-phosphate isomerase {ECO:0000255|HAMAP-Rule:MF_03119}, M1Pi {ECO:0000255|HAMAP-Rule:MF_03119}, MTR-1-P isomerase {ECO:0000255|HAMAP-Rule:MF_03119}, 5.3.1.23 {ECO:0000255|HAMAP-Rule:MF_03119}, Mediator of RhoA-dependent invasion, S-methyl-5-thioribose-1-phosphate isomerase {ECO:0000255|HAMAP-Rule:MF_03119}, Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein {ECO:0000255|HAMAP-Rule:MF_03119}, MRI1 {ECO:0000255|HAMAP-Rule:MF_03119}, MRDI |
| Target/Specificity | The synthetic peptide sequence is selected from aa 128-141 of HUMAN MRI1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MRI1 {ECO:0000255|HAMAP-Rule:MF_03119} |
|---|---|
| Synonyms | MRDI |
| Function | Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover. |
| Cellular Location | Nucleus {ECO:0000255|HAMAP-Rule:MF_03119, ECO:0000269|PubMed:19620624}. Cytoplasm {ECO:0000255|HAMAP- Rule:MF_03119, ECO:0000269|PubMed:19620624}. Cell projection. Note=Primarily nuclear, but cytoplasmic in cancer cells, with enrichment at leading edge of the plasma membrane in late stage tumor cells |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.
References
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Kabuyama Y.,et al.Mol. Cell. Proteomics 8:2308-2320(2009).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
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