NT5M Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9NPB1 |
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Gene ID | 56953 |
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Other Names | 5'(3')-deoxyribonucleotidase, mitochondrial, 5', 3'-nucleotidase, mitochondrial, 3.1.3.-, Deoxy-5'-nucleotidase 2, dNT-2, NT5M, DNT2 |
Target/Specificity | The synthetic peptide sequence is selected from aa 79-90 of HUMAN NT5M |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | NT5M |
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Synonyms | DNT2 |
Function | Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP. |
Cellular Location | Mitochondrion. |
Tissue Location | Highly expressed in heart, brain and skeletal muscle. Detected at very low levels in kidney and pancreas |
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Provided below are standard protocols that you may find useful for product applications.
Background
Dephosphorylates specifically the 5' and 2'(3')- phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.
References
Rampazzo C.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:8239-8244(2000).
Rinaldo-Matthis A.,et al.Nat. Struct. Biol. 9:779-787(2002).
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