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NT5M Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession Q9NPB1
Additional Information
Gene ID 56953
Other Names 5'(3')-deoxyribonucleotidase, mitochondrial, 5', 3'-nucleotidase, mitochondrial, 3.1.3.-, Deoxy-5'-nucleotidase 2, dNT-2, NT5M, DNT2
Target/Specificity The synthetic peptide sequence is selected from aa 79-90 of HUMAN NT5M
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NT5M
Synonyms DNT2
Function Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.
Cellular Location Mitochondrion.
Tissue Location Highly expressed in heart, brain and skeletal muscle. Detected at very low levels in kidney and pancreas
Research Areas
Citations (0)
citation

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Background

Dephosphorylates specifically the 5' and 2'(3')- phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.

References

Rampazzo C.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:8239-8244(2000).
Rinaldo-Matthis A.,et al.Nat. Struct. Biol. 9:779-787(2002).

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$ 277.78
Cat# BP22117c
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