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TXNRD1 Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q16881 |
|---|---|
| Other Accession | O62768, Q9MYY8, Q5NVA2 |
| Gene ID | 7296 |
|---|---|
| Other Names | Thioredoxin reductase 1, cytoplasmic, TR, 1.8.1.9, Gene associated with retinoic and interferon-induced mortality 12 protein, GRIM-12, Gene associated with retinoic and IFN-induced mortality 12 protein, KM-102-derived reductase-like factor, Thioredoxin reductase TR1, TXNRD1, GRIM12, KDRF |
| Target/Specificity | The synthetic peptide sequence is selected from aa 291-305 of HUMAN TXNRD1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TXNRD1 (HGNC:12437) |
|---|---|
| Synonyms | GRIM12, KDRF |
| Function | Reduces disulfideprotein thioredoxin (Trx) to its dithiol- containing form (PubMed:8577704). Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2) (PubMed:10849437). |
| Cellular Location | [Isoform 1]: Cytoplasm [Isoform 5]: Cytoplasm |
| Tissue Location | [Isoform 1]: Expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines |
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Provided below are standard protocols that you may find useful for product applications.
Background
Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
References
Gasdaska P.Y.,et al.FEBS Lett. 373:5-9(1995).
Koishi R.,et al.J. Biol. Chem. 272:2570-2577(1997).
Hofman E.R.,et al.Mol. Cell. Biol. 18:6493-6504(1998).
Rundloef A.-K.,et al.Free Radic. Biol. Med. 36:641-656(2004).
Schuetze N.,et al.Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
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