|Other Accession||Q3T0C7, A9YWH3, Q4R712, Q6DUB7|
|Other Names||Stathmin, Leukemia-associated phosphoprotein p18, Metablastin, Oncoprotein 18, Op18, Phosphoprotein p19, pp19, Prosolin, Protein Pr22, pp17, STMN1, C1orf215, LAP18, OP18|
|Target/Specificity||The synthetic peptide sequence is selected from aa 126-140 of HUMAN STMN1|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||C1orf215, LAP18, OP18|
|Function||Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton.|
|Tissue Location||Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.|
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Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser- 16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).
Zhu X.-X.,et al.J. Biol. Chem. 264:14556-14560(1989).
Maucuer A.,et al.FEBS Lett. 264:275-278(1990).
Melhem R.F.,et al.J. Biol. Chem. 266:17747-17753(1991).
Hosoya H.,et al.Cell Struct. Funct. 21:237-243(1996).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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