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ARL1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P40616
Clone Names 3111908
Additional Information
Gene ID 400
Other Names ADP-ribosylation factor-like protein 1, ARL1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2304c was selected from the C-term region of human ARL1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ARL1
Function GTP-binding protein that recruits several effectors, such as golgins, arfaptins and Arf-GEFs to the trans-Golgi network, and modulates their functions at the Golgi complex (PubMed:9624189, PubMed:21239483, PubMed:27436755, PubMed:22679020, PubMed:27373159). Plays thereby a role in a wide range of fundamental cellular processes, including cell polarity, innate immunity, or protein secretion mediated by arfaptins, which were shown to play a role in maintaining insulin secretion from pancreatic beta cells (PubMed:22981988).
Cellular Location Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane. Membrane; Lipid-anchor
Tissue Location Detected in heart, liver, lung and liver (at protein level). Detected in fetal heart, lung, liver and kidney Detected in adult heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Research Areas
Citations (0)

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Background

ARL1 belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner.

References

Hong, J.X., et al., J. Biol. Chem. 273(25):15872-15876 (1998).Zhang, G.F., et al., J. Biol. Chem. 270(1):21-24 (1995).

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$ 277.78
Cat# BP2304c
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Availability: 2 weeks
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