ARL7 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P56559 |
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Other Accession | NP_005728 |
Clone Names | 3102711 |
Gene ID | 10123 |
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Other Names | ADP-ribosylation factor-like protein 4C, ADP-ribosylation factor-like protein 7, ADP-ribosylation factor-like protein LAK, ARL4C, ARL7 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP2310a was selected from the N-term region of human ARL7 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ARL4C |
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Synonyms | ARL7 |
Function | Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process. |
Cellular Location | Cell projection, filopodium. Cell membrane. Cytoplasm |
Tissue Location | Expressed in several tumor cell lines (at protein level). Expressed in lung, brain, leukocytes and placenta |
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Provided below are standard protocols that you may find useful for product applications.
Background
ADP-ribosylation factor-like 7 is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL7 is closely similar to ARL4 and ARL6 and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate.
References
Jacobs, S., et al., FEBS Lett. 456(3):384-388 (1999).
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