|Other Names||ADP-ribosylation factor-binding protein GGA2, Gamma-adaptin-related protein 2, Golgi-localized, gamma ear-containing, ARF-binding protein 2, VHS domain and ear domain of gamma-adaptin, Vear, GGA2, KIAA1080|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2317a was selected from the N-term region of human GGA2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:10747088). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans- Golgi network (PubMed:15615712).|
|Cellular Location||Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
GGA2 is a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins.
Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).Kalthoff, C., et al., Mol. Biol. Cell 13(11):4060-4073 (2002).Nielsen, M.S., et al., EMBO J. 20(9):2180-2190 (2001).Boman, A.L., et al., Mol. Biol. Cell 11(4):1241-1255 (2000).Hirst, J., et al., J. Cell Biol. 149(1):67-80 (2000).
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