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MGAT2 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q10469
Other Accession NP_002399
Clone Names 3102222
Additional Information
Gene ID 4247
Other Names Alpha-1, 6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, Beta-1, 2-N-acetylglucosaminyltransferase II, GlcNAc-T II, GNT-II, Mannoside acetylglucosaminyltransferase 2, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II, MGAT2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2407a was selected from the N-term region of human MGAT2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MGAT2
Function Plays an essential role in protein N-glycosylation. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) onto the free terminal mannose moiety in the core structure of the nascent N-linked glycan chain, giving rise to the second branch in complex glycans.
Cellular Location Golgi apparatus membrane; Single-pass type II membrane protein
Research Areas
Citations (0)

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Background

MGAT2 (UDP-N-acetylglucosamine:alpha-6-D-mannoside-beta-1, 2-N-acetylglucosaminyltransferase II) is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. Mutations in MGAT2 may lead to carbohydrate-deficient glycoprotein syndrome, type II.

References

Yen, C.L., et al., J. Biol. Chem. 278(20):18532-18537 (2003).Chen, S.H., et al., Glycoconj. J. 15(3):301-308 (1998).Tan, J., et al., Am. J. Hum. Genet. 59(4):810-817 (1996).Tan, J., et al., Eur. J. Biochem. 231(2):317-328 (1995).D'Agostaro, G.A., et al., J. Biol. Chem. 270(25):15211-15221 (1995).

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$ 277.78
Cat# BP2407a
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Availability: 2 weeks
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