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ZMPSTE24 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O75844
Other Accession NP_005848
Clone Names 3092507
Additional Information
Gene ID 10269
Other Names CAAX prenyl protease 1 homolog, Farnesylated proteins-converting enzyme 1, FACE-1, Prenyl protein-specific endoprotease 1, Zinc metalloproteinase Ste24 homolog, ZMPSTE24, FACE1, STE24
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2415a was selected from the Center region of human ZMPSTE24 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZMPSTE24 {ECO:0000303|PubMed:28246125, ECO:0000312|HGNC:HGNC:12877}
Function Transmembrane metalloprotease whose catalytic activity is critical for processing lamin A/LMNA on the inner nuclear membrane and clearing clogged translocons on the endoplasmic reticulum (PubMed:33315887, PubMed:33293369). Proteolytically removes the C- terminal three residues of farnesylated proteins (PubMed:33315887, PubMed:33293369). Plays also an antiviral role independently of its protease activity by restricting enveloped RNA and DNA viruses, including influenza A, Zika, Ebola, Sindbis, vesicular stomatitis, cowpox, and vaccinia (PubMed:28246125, PubMed:28169297). Mechanistically, controls IFITM antiviral pathway to hinder viruses from breaching the endosomal barrier by modulating membrane fluidity (PubMed:35283811).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus inner membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein
Tissue Location Widely expressed. High levels in kidney, prostate, testis and ovary.
Research Areas
Citations (0)
citation

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Background

ZMPSTE24 is a zinc metalloprotease similar to yeast Ste24p. It is an integral membrane protein belonging to peptidase family M48 and is found in the endoplasmic reticulum and possibly in the Golgi compartment. It is thought to be involved in the proteolytic processing of farnesylated proteins.

References

Freije, J.M., et al., Genomics 58(3):270-280 (1999).Kumagai, H., et al., Biochim. Biophys. Acta 1426(3):468-474 (1999).Tam, A., et al., J. Cell Biol. 142(3):635-649 (1998).

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$ 277.78
Cat# BP2415a
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