RCE1 Antibody (N-term W57) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9Y256 |
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Clone Names | 3092510 |
Gene ID | 9986 |
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Other Names | CAAX prenyl protease 2, 3422-, Farnesylated proteins-converting enzyme 2, FACE-2, Prenyl protein-specific endoprotease 2, RCE1 homolog, hRCE1, RCE1, FACE2, RCE1A, RCE1B |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP2416b was selected from the N-term region of human RCE1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | RCE1 |
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Synonyms | FACE2, RCE1A, RCE1B |
Function | Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K- Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (PubMed:10085068). |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
Tissue Location | Ubiquitous.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
RCE1 is an integral membrane protein which is classified as a member of the metalloproteinase family. This enzyme is thought to function in the maintenance and processing of CAAX-type prenylated proteins.
References
Maske, C.P., et al., J. Cell Biol. 162(7):1223-1232 (2003).Hollander, I.J., et al., Biochim. Biophys. Acta 1649(1):24-29 (2003).Freije, J.M., et al., Genomics 58(3):270-280 (1999).Otto, J.C., et al., J. Biol. Chem. 274(13):8379-8382 (1999).
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