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GGPS1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O95749
Other Accession NP_004828
Clone Names 3092626
Additional Information
Gene ID 9453
Other Names Geranylgeranyl pyrophosphate synthase, GGPP synthase, GGPPSase, 251-, (2E, 6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Farnesyltranstransferase, Geranylgeranyl diphosphate synthase, Geranyltranstransferase, GGPS1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2419b was selected from the C-term region of human GGPS1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GGPS1
Function Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.
Cellular Location Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, myofibril, sarcomere, Z line
Tissue Location Abundantly expressed in testis (PubMed:9741684, PubMed:10026212). Found in other tissues to a lower extent (PubMed:9741684, PubMed:10026212). Expressed in dermal fibroblast and skeletal muscle (PubMed:32403198).
Research Areas
Citations (0)
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Background

Geranylgeranyl diphosphate (GGPP) synthase (GGPS) catalyzes the synthesis of GGPP, a molecule responsible for the C20-prenylation of protein and for the regulation of a nuclear hormone receptor. The deduced 300-amino acid human protein contains 5 conserved domains consistent with prenyltransferases. Recombinant GGPS shows enzymatic properties associated with the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. Mouse GGPS is regulated in several tissues in obesity and is induced during adipocyte differentiation. GGPS is increased 5- to 20-fold in skeletal muscle, liver, and fat of ob/ob mice. Western blot analysis detects a 2-fold overexpression of protein in muscle and fat but not in liver. Differentiation of mouse fibroblasts into adipocytes induces GGPS expression more than 20-fold.

References

Kainou, T., et al., Biochim. Biophys. Acta 1437(3):333-340 (1999).Kuzuguchi, T., et al., J. Biol. Chem. 274(9):5888-5894 (1999).Ericsson, J., et al., J. Lipid Res. 39(9):1731-1739 (1998).

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$ 277.78
Cat# BP2419b
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