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Myb Sumoylation Site Antibody Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P10242 |
|---|---|
| Clone Names | 2110404 |
| Gene ID | 4602 |
|---|---|
| Other Names | Transcriptional activator Myb, Proto-oncogene c-Myb, MYB |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP2500a was selected from the region of a human Myb sumoylation site. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MYB |
|---|---|
| Function | Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:19646965} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Myb is a transcriptional activator; DNA-binding protein that recognizes the sequence 5'-YAAC[GT]G-3'. It participates in the control of proliferation and differentiation of hematopoietic progenitor cells. Myb is a transcription factor related to Myc, and is expressed predominantly in haematopoietic cells and immature gastroepithelial cells. TRAF7 stimulates the sumoylation of Myb at Lys-523 and Lys-499, which are the same sites as those used for PIASy-induced sumoylation. A correlation has been established between reduction in sumoylation of Myb and increase in transcriptional activation. Negative influence on transactivation properties by the negative regulatory domain region of c-Myb depends on upon sumoylation.
References
Luchetti, M.M., et al., J. Biol. Chem. 278(3):1533-1541 (2003).Dahle, O., et al., Eur. J. Biochem. 270(6):1338-1348 (2003).Chen, J., et al., Oncogene 21(12):1859-1869 (2002).Hernandez-Munain, C., et al., J. Immunol. 169(8):4362-4369 (2002).Tanno, B., et al., J. Biol. Chem. 277(26):23172-23180 (2002).
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