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Myb Sumoylation Site Antibody Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P10242
Clone Names 2110404
Additional Information
Gene ID 4602
Other Names Transcriptional activator Myb, Proto-oncogene c-Myb, MYB
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2500a was selected from the region of a human Myb sumoylation site. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MYB
Function Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
Cellular Location Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:19646965}
Research Areas
Citations (0)

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Myb is a transcriptional activator; DNA-binding protein that recognizes the sequence 5'-YAAC[GT]G-3'. It participates in the control of proliferation and differentiation of hematopoietic progenitor cells. Myb is a transcription factor related to Myc, and is expressed predominantly in haematopoietic cells and immature gastroepithelial cells. TRAF7 stimulates the sumoylation of Myb at Lys-523 and Lys-499, which are the same sites as those used for PIASy-induced sumoylation. A correlation has been established between reduction in sumoylation of Myb and increase in transcriptional activation. Negative influence on transactivation properties by the negative regulatory domain region of c-Myb depends on upon sumoylation.


Luchetti, M.M., et al., J. Biol. Chem. 278(3):1533-1541 (2003).Dahle, O., et al., Eur. J. Biochem. 270(6):1338-1348 (2003).Chen, J., et al., Oncogene 21(12):1859-1869 (2002).Hernandez-Munain, C., et al., J. Immunol. 169(8):4362-4369 (2002).Tanno, B., et al., J. Biol. Chem. 277(26):23172-23180 (2002).

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$ 277.78
Cat# BP2500a
Availability: 2 weeks
Bulk Size

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