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ACOX1 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q15067
Clone Names 3083109
Additional Information
Gene ID 51
Other Names Peroxisomal acyl-coenzyme A oxidase 1, AOX, Palmitoyl-CoA oxidase, Straight-chain acyl-CoA oxidase, SCOX, ACOX1, ACOX
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2523a was selected from the N-term region of human ACOX1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ACOX1 (HGNC:119)
Synonyms ACOX
Function Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl- CoAs.
Cellular Location Peroxisome {ECO:0000250|UniProtKB:P07872}.
Tissue Location Widely expressed with highest levels of isoform 1 and isoform 2 detected in testis. Isoform 1 is expressed at higher levels than isoform 2 in liver and kidney while isoform 2 levels are higher in brain, lung, muscle, white adipose tissue and testis. Levels are almost equal in heart.
Research Areas
Citations (0)

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Background

ACOX1 is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donateselectrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids.

References

Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).Chu, R., et al., J. Biol. Chem. 270(9):4908-4915 (1995).Aoyama, T., et al., Biochem. Biophys. Res. Commun. 198(3):1113-1118 (1994).Fournier, B., et al., J. Clin. Invest. 94(2):526-531 (1994).Varanasi, U., et al., Proc. Natl. Acad. Sci. U.S.A. 91(8):3107-3111 (1994).

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$ 277.78
Cat# BP2523a
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Availability: 2 weeks
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