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PPT2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UMR5 |
|---|---|
| Other Accession | PPT2_HUMAN |
| Clone Names | 3090807 |
| Gene ID | 9374 |
|---|---|
| Other Names | Lysosomal thioesterase PPT2, PPT-2, 312-, S-thioesterase G14, PPT2 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP2539a was selected from the N-term region of human PPT2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PPT2 (HGNC:9326) |
|---|---|
| Function | Catalyzes the cleavage of thioester bonds from S-palmitoyl- CoA or S-palmitoyl-N-acetylcysteamine (unbranched structures) but does not have activity against palmitoylcysteine or palmitoylated proteins, branched structures or bulky head groups. Conversely, hydrolyzes both long and short chain fatty acyl-CoA substrate. |
| Cellular Location | Lysosome. |
| Tissue Location | Broadly expressed, with highest levels in skeletal muscle. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
PPT2 removes thioester-linked fatty acyl groups from modified cysteine residues in proteins and prefers the acyl groups palmitic and myristic acid over other long-chain acyl substrates. It is a glycosylated lysosomal protein and member of the palmitoyl-protein thioesterase family.
References
Clark, H.F., et al., Genome Res. 13(10):2265-2270 (2003).Calero, G., et al., J. Biol. Chem. 278(39):37957-37964 (2003).Soyombo, A.A., et al., Genomics 56(2):208-216 (1999).Soyombo, A.A., et al., J. Biol. Chem. 272(43):27456-27463 (1997).Aguado, B., et al., Biochem. J. 341 (Pt 3), 679-689 (1999).
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