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ZBRK1 (Center) Antibody Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9GZX5
Clone Names 2103125
Additional Information
Gene ID 59348
Other Names Zinc finger protein 350, KRAB zinc finger protein ZFQR, Zinc finger and BRCA1-interacting protein with a KRAB domain 1, Zinc finger protein ZBRK1, ZNF350, ZBRK1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2547a was selected from the Center region of human ZBRK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZNF350
Synonyms ZBRK1
Function Transcriptional repressor. Binds to a specific sequence, 5'- GGGxxxCAGxxxTTT-3', within GADD45 intron 3.
Cellular Location Nucleus. Nucleus matrix. Note=Associated with the nuclear matrix
Tissue Location Widely expressed..
Research Areas
Citations (0)

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ZBRK1 binds to a specific sequence, GGGxxxCAGxxxTTT, within GADD45 intron 3 that supports the assembly of a nuclear complex minimally containing both ZBRK1 and BRCA1. Through this recognition sequence, ZBRK1 represses transcription in a BRCA1-dependent manner. The results revealed a novel corepressor function for BRCA1 and provided a mechanistic basis for the biologic activity of BRCA1 through sequence-specific transcriptional regulation.


Liao, G., et al., J. Virol. 79(1):245-256 (2005).Tan, W., et al., J. Biol. Chem. 279(8):6576-6587 (2004).Yun, J., et al., Mol. Cell. Biol. 23(20):7305-7314 (2003).Rutter, J.L., et al., Hum. Mutat. 22(2):121-128 (2003).Ran, Q., et al., Exp. Cell Res. 263(1):156-162 (2001).

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$ 277.78
Cat# BP2547a
Availability: 2 weeks
Bulk Size

Ordering Information

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