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MATH1/HATH1/ATOH1 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q92858
Clone Names 6071506
Additional Information
Other Names Protein atonal homolog 1, Class A basic helix-loop-helix protein 14, bHLHa14, Helix-loop-helix protein hATH-1, hATH1, ATOH1, ATH1, BHLHA14
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2702b was selected from the C-term region of human ATOH1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATOH1
Synonyms ATH1, BHLHA14
Function Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).
Cellular Location Nucleus. EMBL; U61148; AAB41305.1; -; Genomic_DNA EMBL; BC069145; AAH69145.1; -; mRNA EMBL; BC069594; AAH69594.1; -; mRNA EMBL; BC069604; AAH69604.1; -; mRNA EMBL; BC113623; AAI13624.1; -; mRNA EMBL; BC113625; AAI13626.1; -; mRNA CCDS; CCDS3638.1; - RefSeq; NP_005163.1; NM_005172.1 SMR; Q92858; - BioGRID; 106964; 76 STRING; 9606.ENSP00000302216; - iPTMnet; Q92858; - PhosphoSitePlus; Q92858; - BioMuta; ATOH1; - DMDM; 3913115; - jPOST; Q92858; - MassIVE; Q92858; - PaxDb; Q92858; - PeptideAtlas; Q92858; - PRIDE; Q92858; - ProteomicsDB; 75551; - Antibodypedia; 25709; 532 antibodies DNASU; 474; - Ensembl; ENST00000306011; ENSP00000302216; ENSG00000172238 GeneID; 474; - KEGG; hsa:474; - UCSC; uc003hta.2; human CTD; 474; - DisGeNET; 474; - EuPathDB; HostDB:ENSG00000172238.4; - GeneCards; ATOH1; - HGNC; HGNC:797; ATOH1 HPA; ENSG00000172238; Tissue enriched (intestine) MIM; 601461; gene neXtProt; NX_Q92858; - OpenTargets; ENSG00000172238; - PharmGKB; PA25095; - eggNOG; KOG4395; Eukaryota GeneTree; ENSGT00940000160064; - HOGENOM; CLU_083039_0_0_1; - InParanoid; Q92858; - KO; K09083; - OMA; PHSHFSD; - OrthoDB; 926106at2759; - PhylomeDB; Q92858; - TreeFam; TF315153; - PathwayCommons; Q92858; - SIGNOR; Q92858; - BioGRID-ORCS; 474; 14 hits in 886 CRISPR screens GeneWiki; ATOH1; - GenomeRNAi; 474; - Pharos; Q92858; Tbio PRO; PR:Q92858; - Proteomes; UP000005640; Chromosome 4 RNAct; Q92858; protein Bgee; ENSG00000172238; Expressed in mucosa of transverse colon and 20 other tissues Genevisible; Q92858; HS GO; GO:0000790; C:nuclear chromatin; ISA:NTNU_SB GO; GO:0005634; C:nucleus; ISS:UniProtKB GO; GO:0031490; F:chromatin DNA binding; IEA:Ensembl GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:ProtInc GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB GO; GO:0046983; F:protein dimerization activity; IEA:InterPro GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL GO; GO:0042668; P:auditory receptor cell fate determination; IEA:Ensembl GO; GO:0042667; P:auditory receptor cell fate specification; IEA:Ensembl GO; GO:0007411; P:axon guidance; IEA:Ensembl GO; GO:0007417; P:central nervous system development; TAS:ProtInc GO; GO:0021987; P:cerebral cortex development; IEA:Ensembl GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl GO; GO:0001764; P:neuron migration; IEA:Ensembl GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl GO; GO:0045609; P:positive regulation of inner ear auditory receptor cell differentiation; IEA:Ensembl GO; GO:0045666; P:positive regulation of neuron differentiation; ISS:UniProtKB GO; GO:0006366; P:transcription by RNA polymerase II; TAS:ProtInc CDD; cd00083; HLH; 1 Gene3D; 4.10.280.10; -; 1 InterPro; IPR032661; ATOH1 InterPro; IPR011598; bHLH_dom InterPro; IPR036638; HLH_DNA-bd_sf PANTHER; PTHR19290:SF82; PTHR19290:SF82; 1 Pfam; PF00010; HLH; 1 SMART; SM00353; HLH; 1 SUPFAM; SSF47459; SSF47459; 1 PROSITE; PS50888; BHLH; 1 2: Evidence at transcript level; Activator; Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation CHAIN 1..354 /note="Protein atonal homolog 1" /id="PRO_0000127139" DOMAIN 159..211 /note="bHLH" /evidence="ECO:0000255|PROSITE-ProRule:PRU00981" COMPBIAS 29..38 /note="Poly-Pro" COMPBIAS 224..228 /note="Poly-Pro" VARIANT 237 /note="H -> Q (in dbSNP:rs35182771)" /id="VAR_049539" SEQUENCE 354 AA; 38160 MW; AB12F1E917A00A8D CRC64; MSRLLHAEEW AEVKELGDHH RQPQPHHLPQ PPPPPQPPAT LQAREHPVYP PELSLLDSTD PRAWLAPTLQ GICTARAAQY LLHSPELGAS EAAAPRDEVD GRGELVRRSS GGASSSKSPG PVKVREQLCK LKGGVVVDEL GCSRQRAPSS KQVNGVQKQR RLAANARERR RMHGLNHAFD QLRNVIPSFN NDKKLSKYET LQMAQIYINA LSELLQTPSG GEQPPPPPAS CKSDHHHLRT AASYEGGAGN ATAAGAQQAS GGSQRPTPPG SCRTRFSAPA SAGGYSVQLD ALHFSTFEDS ALTAMMAQKN LSPSLPGSIL QPVQEENSKT SPRSHRSDGE FSPHSHYSDS DEAS
Research Areas
Citations (0)

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Background

ATOH1 belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47.

References

Aragaki,M.,Biochem. Biophys. Res. Commun. 368 (4), 923-929 (2008)Scheffer,D., FEBS Lett. 581 (24), 4651-4656 (2007)

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$ 277.78
Cat# BP2702b
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