|Other Names||Prohibitin, PHB|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2710a was selected from the N-term region of human PHB1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Protein with pleiotropic attributes mediated in a cell- compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (PubMed:11302691, PubMed:20959514, PubMed:28017329, PubMed:31522117). Plays a role in adipose tissue and glucose Homeostasis in a sex-specific manner (By similarity). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity).|
|Cellular Location||Mitochondrion inner membrane. Nucleus. Cytoplasm. Cell membrane|
|Tissue Location||Widely expressed in different tissues.|
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Provided below are standard protocols that you may find useful for product applications.
Prohibitin is an evolutionarily conserved protein that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region.
Gregory-Bass,R.C., Int. J. Cancer 122 (9), 1923-1930 (2008)Ross,J.A., J. Biol. Chem. 283 (8), 4699-4713 (2008)White,J.J., Genomics 11 (1), 228-230 (1991)
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