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Prohibitin (PHB1) Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P35232
Clone Names 6072325
Additional Information
Gene ID 5245
Other Names Prohibitin, PHB
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2710a was selected from the N-term region of human PHB1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PHB (HGNC:8912)
Function Protein with pleiotropic attributes mediated in a cell- compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (PubMed:11302691, PubMed:20959514, PubMed:28017329, PubMed:31522117). Plays a role in adipose tissue and glucose Homeostasis in a sex-specific manner (By similarity). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity).
Cellular Location Mitochondrion inner membrane. Nucleus. Cytoplasm. Cell membrane
Tissue Location Widely expressed in different tissues.
Research Areas
Citations (0)

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Background

Prohibitin is an evolutionarily conserved protein that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region.

References

Gregory-Bass,R.C., Int. J. Cancer 122 (9), 1923-1930 (2008)Ross,J.A., J. Biol. Chem. 283 (8), 4699-4713 (2008)White,J.J., Genomics 11 (1), 228-230 (1991)

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$ 277.78
Cat# BP2710a
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Availability: 2 weeks
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