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Deaf1 Blocking Peptide (C-term)

Synthetic peptide

Product Information
Primary Accession Q9Z1T5
Other Accession O88450
Additional Information
Gene ID 54006
Other Names Deformed epidermal autoregulatory factor 1 homolog, Nuclear DEAF-1-related transcriptional regulator, NUDR, Deaf1
Target/Specificity The synthetic peptide sequence is selected from aa 383-400 of MOUSE Deaf1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Deaf1
Function Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction (By similarity). Regulates epithelial cell proliferation and side-branching in the mammary gland. Required for neural tube closure and skeletal patterning. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 2. Isoform 2 may inhibit transcriptional activity of isoform 1 by interacting with it and retaining it in the cytoplasm. Transcriptional activator of EIF4G3 (By similarity). May also involved in behavior (PubMed:24726472).
Cellular Location [Isoform 1]: Nucleus. Cytoplasm.
Tissue Location Ubiquitously expressed during embryogenesis, with higher expression in regions of the central nervous system, dorsal root ganglia, submandibular gland, epidermis and breast. In 12-week-old NOD mice, expression of isoform 2 is sevenfold higher in lymph node stromal elements than in T-cells and tenfold higher than in B-cells
Research Areas
Citations (0)

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Drosophila Deformed epidermal autoregulatory factor 1 (DEAF-1) is a DNA-binding protein that interacts with regulatory sequences first described in the Deformed epidermal autoregulatory element.


Czesak,M.,J. Neurosci. 26 (6), 1864-1871 (2006)
Hahm,K., Mol. Cell. Biol. 24 (5), 2074-2082 (2004)

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$ 277.78
Cat# BP2711b
Availability: 2 weeks
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