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Semaphorin 5A Antibody Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q13591
Clone Names 80130152
Additional Information
Gene ID 9037
Other Names Semaphorin-5A, Semaphorin-F, Sema F, SEMA5A, SEMAF
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2712c was selected from the S106 region of human Semaphorin 5A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SEMA5A
Synonyms SEMAF
Function Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.
Cellular Location Membrane; Single-pass type I membrane protein.
Research Areas
Citations (0)

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Background

Semaphorin 5A belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development.

References

Weiss,L.A., et.al., Nature 461 (7265), 802-808 (2009).

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$ 277.78
Cat# BP2712c
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Availability: 2 weeks
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