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SPRED2 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q7Z698
Clone Names 70319164
Additional Information
Gene ID 200734
Other Names Sprouty-related, EVH1 domain-containing protein 2, Spred-2, SPRED2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2732b was selected from the C-term region of human SPRED2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:15683364). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:Q924S7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q924S7}; Cytoplasmic side {ECO:0000250|UniProtKB:Q924S7}. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Detected in the cytoplasm of the stratum spinosum cells, where it is associated with cytoplasmic vesicles that are supposed to be secretory granules
Tissue Location Expressed in liver, skin, small intestine, salivary gland and prostate.
Research Areas
Citations (0)

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SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).


Lock,P., Biochem. Biophys. Res. Commun. 351 (4), 1018-1023 (2006)Yoshida,T., Oncogene 25 (45), 6056-6066 (2006)Bundschu,K., J. Biol. Chem. 280 (31), 28572-28580 (2005)

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$ 277.78
Cat# BP2732b
Availability: 2 weeks
Bulk Size

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