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Vimentin Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P08670
Clone Names 80220179
Additional Information
Gene ID 7431
Other Names Vimentin, VIM
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2739c was selected from the Center region of human Vimentin. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name VIM
Function Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton. Nucleus matrix {ECO:0000250|UniProtKB:P31000}. Cell membrane {ECO:0000250|UniProtKB:P20152}
Tissue Location Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines.
Research Areas
Citations (0)
citation

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Background

Along with the microfilaments (actins) and microtubules (tubulins), the intermediate filaments represent a third class of well-characterized cytoskeletal elements. The subunits display a tissue-specific pattern of expression. Desmin (MIM 125660) is the subunit specific for muscle and vimentin the subunit specific for mesenchymal tissue.

References

Whipple,R.A.,Cancer Res. 68 (14), 5678-5688 (2008)Garcia-Verdugo,I.,Biochemistry 47 (18), 5127-5138 (2008)Merdes,A., J. Cell Biol. 115 (2), 397-410 (1991)

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$ 277.78
Cat# BP2739c
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Availability: 2 weeks
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