B2M Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P61769 |
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Clone Names | 80102135 |
Gene ID | 567 |
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Other Names | Beta-2-microglobulin, Beta-2-microglobulin form pI 53, B2M |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP2771a was selected from the N-term region of human B2M. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | B2M (HGNC:914) |
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Function | Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). |
Cellular Location | Secreted. Cell surface. Note=Detected in serum and urine (PubMed:1336137, PubMed:7554280). {ECO:0000269|PubMed:7554280, ECO:0000269|Ref.6} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Beta-2-microglobulin is a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells.
References
Sakata,M., J. Mol. Biol. 382 (5), 1242-1255 (2008)Huang,W.C., Clin. Cancer Res. 14 (17), 5341-5347 (2008)Gattoni-Celli,S., Cancer Res. 52 (5), 1201-1204 (1992)
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