IVD Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P26440 |
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Other Accession | NP_002216 |
Clone Names | 81205067 |
Gene ID | 3712 |
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Other Names | Isovaleryl-CoA dehydrogenase, mitochondrial, IVD, IVD |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | IVD (HGNC:6186) |
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Function | Catalyzes the conversion of isovaleryl-CoA/3-methylbutanoyl- CoA to 3-methylbut-2-enoyl-CoA as an intermediate step in the leucine (Leu) catabolic pathway (PubMed:7640268). To a lesser extent, is also able to catalyze the oxidation of other saturated short-chain acyl-CoA thioesters as pentanoyl-CoA, hexenoyl-CoA and butenoyl-CoA (PubMed:7640268). |
Cellular Location | Mitochondrion matrix {ECO:0000250|UniProtKB:P12007} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Isovaleryl-CoA dehydrogenase (IVD) is a mitochondrialmatrix enzyme that catalyzes the third step in leucine catabolism.The genetic deficiency of IVD results in an accumulation ofisovaleric acid, which is toxic to the central nervous system andleads to isovaleric acidemia. Alternatively spliced transcriptvariants encoding different isoforms have been found for this gene.
References
Matsubara, Y., et al. J. Clin. Invest. 85(4):1058-1064(1990)Kraus, J.P., et al. Genomics 1(3):264-269(1987)Ikeda, Y., et al. J. Biol. Chem. 258(2):1077-1085(1983)
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