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Phospho-APG8c(MAP1LC3C)(Y105) Antibody Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BXW4 |
|---|---|
| Clone Names | 80317113 |
| Gene ID | 440738 |
|---|---|
| Other Names | Microtubule-associated proteins 1A/1B light chain 3C, Autophagy-related protein LC3 C, Autophagy-related ubiquitin-like modifier LC3 C, MAP1 light chain 3-like protein 3, MAP1A/MAP1B light chain 3 C, MAP1A/MAP1B LC3 C, Microtubule-associated protein 1 light chain 3 gamma, MAP1LC3C |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP3691a was selected from the MAP1LC3C-Y105 region of human Phospho-APG8c (MAP1LC3C)-Y105. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MAP1LC3C |
|---|---|
| Function | Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2 (PubMed:23022382). Recruits all ATG8 family members to infecting bacteria such as S.typhimurium (PubMed:23022382). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins (PubMed:28404643). |
| Cellular Location | Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Endomembrane system; Lipid-anchor. Cytoplasm, cytoskeleton. Note=LC3-II binds to the autophagic membranes. |
| Tissue Location | Most abundant in placenta, lung and ovary. |
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Provided below are standard protocols that you may find useful for product applications.
Background
APG8c is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. APG8c is 1 of 3 orthologs of the yeast autophagosome protein Atg8.
References
Tanida,I., et.al, J. Biol. Chem. 279 (35), 36268-36276 (2004)He,H., et.al, J. Biol. Chem. 278 (31), 29278-29287 (2003)
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