Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
Phospho-NR3C1(S211) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P04150 |
|---|---|
| Other Accession | P06537, NP_001018085.1, NP_001018087.1 |
| Gene ID | 2908 |
|---|---|
| Other Names | Glucocorticoid receptor, GR, Nuclear receptor subfamily 3 group C member 1, NR3C1, GRL |
| Target/Specificity | The synthetic peptide sequence is selected from aa 207-217 of HUMAN NR3C1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NR3C1 (HGNC:7978) |
|---|---|
| Synonyms | GRL |
| Function | Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). |
| Cellular Location | [Isoform Alpha]: Cytoplasm. Nucleus. Mitochondrion. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=After ligand activation, translocates from the cytoplasm to the nucleus. In the presence of NR1D1 shows a time-dependent subcellular localization, localizing to the cytoplasm at ZT8 and to the nucleus at ZT20 (By similarity). Lacks this diurnal pattern of localization in the absence of NR1D1, localizing to both nucleus and the cytoplasm at ZT8 and ZT20 (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:18838540, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:8621628} [Isoform Alpha-B]: Nucleus. Cytoplasm Note=After ligand activation, translocates from the cytoplasm to the nucleus. |
| Tissue Location | Widely expressed including bone, stomach, lung, liver, colon, breast, ovary, pancreas and kidney (PubMed:25847991). In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart (PubMed:10902803) [Isoform Alpha-2]: Widely expressed. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined.
References
Bosker, F.J., et al. Mol. Psychiatry (2010) In press :
Inkster, B., et al. Neuroimage (2010) In press :
Geelhoed, M.J., et al. BMC Med. Genet. 11, 39 (2010) :
Te Winkel, M.L., et al. Haematologica (2009) In press :
Szilagyi, K., et al. Neuro Endocrinol. Lett. 30(5):629-636(2009)
Tian, S., et al. Biochem. J. 367 (PT 3), 907-911 (2002) :
Itoh, M., et al. Mol. Endocrinol. 16(10):2382-2392(2002)
Wang, Z., et al. J. Biol. Chem. 277(29):26573-26580(2002)
Wallace, A.D., et al. J. Biol. Chem. 276(46):42714-42721(2001)
Krstic, M.D., et al. Mol. Cell. Biol. 17(7):3947-3954(1997)
Giffin, W., et al. J. Biol. Chem. 272(9):5647-5658(1997)
Bodwell, J.E., et al. J. Steroid Biochem. Mol. Biol. 52(2):135-140(1995)
Subramaniam, M., et al. J. Cell. Biochem. 50(4):411-424(1992)
Cadepond, F., et al. Exp. Cell Res. 201(1):99-108(1992)
Scherrer, L.C., et al. J. Steroid Biochem. Mol. Biol. 41 (3-8), 719-721 (1992) :
Bodwell, J.E., et al. J. Biol. Chem. 266(12):7549-7555(1991)
Hurley, D.M., et al. J. Clin. Invest. 87(2):680-686(1991)
Plotkin, L.L., et al. Med Tekh 3, 42-43 (1975) :
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
