WDR82 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q6UXN9 |
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Gene ID | 80335 |
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Other Names | WD repeat-containing protein 82, Protein TMEM113, Swd2, WDR82, TMEM113, WDR82A |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | WDR82 {ECO:0000303|PubMed:17998332, ECO:0000312|HGNC:HGNC:28826} |
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Function | Regulatory component of the SET1/COMPASS complex implicated in the tethering of this complex to transcriptional start sites of active genes (PubMed:17998332, PubMed:18838538, PubMed:20516061). Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A) (PubMed:17998332, PubMed:18838538). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). Together with ZC3H4, but independently of the SET1 complex, part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs) (PubMed:33913806, PubMed:33767452). The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs and promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452). |
Cellular Location | Nucleus. Chromosome {ECO:0000250|UniProtKB:Q8BFQ4}. Note=Associates with chromatin (PubMed:20516061). Recruited at sites of high RNA polymerase II occupancy (By similarity). {ECO:0000250|UniProtKB:Q8BFQ4, ECO:0000269|PubMed:20516061} |
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Provided below are standard protocols that you may find useful for product applications.
Background
WDR82 is a component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferase complexes.
References
Wu, M., et al. Mol. Cell. Biol. 28(24):7337-7344(2008)Lee, J.H., et al. Mol. Cell. Biol. 28(2):609-618(2008)Higa, L.A., et al. Nat. Cell Biol. 8(11):1277-1283(2006)
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