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SDCG3 Blocking Peptide (N-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96C92 |
|---|
| Gene ID | 10807 |
|---|---|
| Other Names | Serologically defined colon cancer antigen 3, Antigen NY-CO-3, SDCCAG3 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 86-99 of HUMAN SDCCAG3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ENTR1 (HGNC:10667) |
|---|---|
| Synonyms | SDCCAG3 |
| Function | Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis (PubMed:23108400, PubMed:25278552, PubMed:27767179). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (PubMed:23108400). Plays a role in the formation of cilia (PubMed:27767179). Involved in cargo protein localization, such as PKD2, at primary cilia (PubMed:27767179). Involved in the presentation of the tumor necrosis factor (TNF) receptor TNFRSF1A on the cell surface, and hence in the modulation of the TNF-induced apoptosis (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:A2AIW0}. Early endosome. Endosome. Recycling endosome. Midbody Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body Note=Colocalizes in a WASHC2-dependent manner with the retromer CSC complex at endosomes (PubMed:25278552). During cytokinesis colocalized with PTPN13 at the midbody (PubMed:23108400). Colocalizes with IFT88 and gamma-tubulin at the basal body of primary cilia (PubMed:27767179) Colocalizes with IFT88 and pericentrin at the centrosome (PubMed:27767179). |
| Tissue Location | Expressed in the colon (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
SDCG3 may be involved in modulation of TNF response. SDCG3 may be involved in presentation of TNFRSF1A on the cell surface.
References
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Neznanov, N., et al. DNA Cell Biol. 24(12):777-785(2005)
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