K0146 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q14159 |
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Gene ID | 23514 |
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Other Names | DNA repair-scaffolding protein, Scaffolding protein involved in DNA repair, SPIDR, KIAA0146 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SPIDR |
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Synonyms | KIAA0146 |
Function | Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity. |
Cellular Location | Nucleus. Note=Together with BLM, is redistributed in discrete nuclear DNA damage-induced foci following hydroxyurea (HU) or camptothecin (CPT) treatment |
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Provided below are standard protocols that you may find useful for product applications.
References
Tang, B.S., et al. J. Virol. 79(10):6180-6193(2005)Lee, Y.W., et al. Mol. Med. 10 (1-6), 19-27 (2004)
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