ITPA Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9BY32 |
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Gene ID | 3704 |
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Other Names | Inosine triphosphate pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}, ITPase {ECO:0000255|HAMAP-Rule:MF_03148}, Inosine triphosphatase {ECO:0000255|HAMAP-Rule:MF_03148}, 36119 {ECO:0000255|HAMAP-Rule:MF_03148}, Non-canonical purine NTP pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}, Non-standard purine NTP pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}, Nucleoside-triphosphate diphosphatase {ECO:0000255|HAMAP-Rule:MF_03148}, Nucleoside-triphosphate pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}, NTPase {ECO:0000255|HAMAP-Rule:MF_03148}, Putative oncogene protein hlc14-06-p, ITPA {ECO:0000255|HAMAP-Rule:MF_03148}, C20orf37 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ITPA {ECO:0000255|HAMAP-Rule:MF_03148} |
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Synonyms | C20orf37 |
Function | Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. |
Cellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03148, ECO:0000269|PubMed:11278832} |
Tissue Location | Ubiquitous. Highly expressed in heart, liver, sex glands, thyroid and adrenal gland |
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Provided below are standard protocols that you may find useful for product applications.
Background
ITPA hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. The encoded protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency. Two transcript variants encoding two different isoforms have been found for this gene.
References
Fellay, J., et al. Nature 464(7287):405-408(2010)Herting, G., et al. Biochim. Biophys. Acta 1802(2):269-274(2010)Kudo, M., et al. Drug Metab. Pharmacokinet. 24(6):557-564(2009)
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