FARS2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O95363 |
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Gene ID | 10667 |
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Other Names | Phenylalanine--tRNA ligase, mitochondrial, Phenylalanyl-tRNA synthetase, PheRS, FARS2, FARS1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | FARS2 |
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Synonyms | FARS1 |
Function | Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins. |
Cellular Location | Mitochondrion matrix {ECO:0000250|UniProtKB:Q6AYQ3}. Mitochondrion {ECO:0000250|UniProtKB:Q6AYQ3} |
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Provided below are standard protocols that you may find useful for product applications.
Background
FARS2 is a phenylalanine-tRNA synthetase (PheRS) localized to the mitochondrion which consists of a single polypeptide chain, unlike the (alpha-beta)2 structure of the prokaryotic and eukaryotic cytoplasmic forms of PheRS. Structure analysis and catalytic properties indicate mitochondrial PheRSs may constitute a class of PheRS distinct from the enzymes found in prokaryotes and in the eukaryotic cytoplasm.
References
Yadavalli, S.S., et al. FEBS Lett. 583(19):3204-3208(2009)Klipcan, L., et al. Proc. Natl. Acad. Sci. U.S.A. 106(27):11045-11048(2009)Finarov, I., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65 (PT 2), 93-97 (2009)
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