HELLS Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9NRZ9 |
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Other Accession | NP_060533 |
Clone Names | 80109125 |
Gene ID | 3070 |
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Other Names | Lymphoid-specific helicase, 364-, Proliferation-associated SNF2-like protein, SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6, HELLS (HGNC:4861) |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | HELLS (HGNC:4861) |
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Function | Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity). |
Cellular Location | Nucleus. Note=Closely associated with pericentric heterochromatin. |
Tissue Location | Highly expressed in proliferative tissues such as adult thymus and testis, and expressed at lower levels in uterus, small intestine, colon, and peripheral blood mononuclear cells. Also expressed in neoplastic cell lines including those derived from myeloid and lymphoid leukemias. |
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Provided below are standard protocols that you may find useful for product applications.
Background
HELLS is a lymphoid-specific helicase. Otherhelicases function in processes involving DNA strand separation,including replication, repair, recombination, and transcription.This protein is thought to be involved with cellular proliferationand may play a role in leukemogenesis.
References
Zhou, R., et al. Nucleic Acids Res. 37(15):5183-5196(2009)Palmieri, R.T., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3567-3572(2008)Suzuki, T., et al. Epigenetics 3(5):281-291(2008)Geiman, T.M., et al. Genomics 54(3):477-483(1998)
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