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PYHIN1 Blocking Peptide (N-term)

Synthetic peptide

Product Information
Primary Accession Q6K0P9
Other Accession Q16666, NP_945146.1, NP_945148.1
Additional Information
Gene ID 149628
Other Names Pyrin and HIN domain-containing protein 1, Interferon-inducible protein X, PYHIN1, IFIX
Target/Specificity The synthetic peptide sequence is selected from aa 41-55 of HUMAN PYHIN1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms IFIX
Function Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.
Cellular Location [Isoform 1]: Nucleus, nucleoplasm. [Isoform 5]: Nucleus. Nucleus speckle.
Tissue Location Expressed in spleen, lymph node and peripheral blood leukocytes, and at lower levels in thymus, bone marrow and fetal liver. Down-regulated in breast tumors.
Research Areas
Citations (0)

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PYHIN1 belongs to the HIN200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-terminal ends. HIN200 proteins are primarily nuclear and are involved in transcriptional regulation of genes important for cell cycle control, differentiation, and apoptosis (Ding et al., 2006 [PubMed 16479015]).


Yamaguchi, H., et al. Mol. Carcinog. 47(10):739-743(2008)
Ding, Y., et al. Mol. Cell. Biol. 26(5):1979-1996(2006)
Ding, Y., et al. Oncogene 23(26):4556-4566(2004)

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$ 277.78
Cat# BP5376a
Availability: 2 weeks
Bulk Size

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