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NEURL1B Blocking Peptide (N-term)

Synthetic peptide

     
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Product Information
Primary Accession A8MQ27
Other Accession Q0MW30, NP_001136123.1
Additional Information
Other Names E3 ubiquitin-protein ligase NEURL1B, 632-, Neuralized-2, NEUR2, Neuralized-like protein 1B, Neuralized-like protein 3, NEURL1B, NEURL3
Target/Specificity The synthetic peptide sequence is selected from aa 71-85 of HUMAN NEURL1B
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NEURL1B
Synonyms NEURL3
Function E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands.
Cellular Location Cytoplasm.
Tissue Location Highest expression in brain, prostate and small intestine. In the brain the levels are higher in fetal than in adult stage. In the adult brain the highest levels are detected in the olfactory system, cerebellar cortex, optic nerve and the frontal lobe EMBL; GQ414757; ACV53563.1; -; mRNA EMBL; GQ414758; ACV53564.1; -; mRNA EMBL; GQ414759; ACV53565.1; -; mRNA EMBL; AC027309; -; NOT_ANNOTATED_CDS; Genomic_DNA CCDS; CCDS47342.1; -. [A8MQ27-1] CCDS; CCDS78085.1; -. [A8MQ27-3] CCDS; CCDS83042.1; -. [A8MQ27-2] RefSeq; NP_001136123.1; NM_001142651.2. [A8MQ27-1] RefSeq; NP_001295106.1; NM_001308177.1. [A8MQ27-2] RefSeq; NP_001295107.1; NM_001308178.1. [A8MQ27-3] SMR; A8MQ27; - BioGRID; 119989; 3 STRING; 9606.ENSP00000358815; - iPTMnet; A8MQ27; - PhosphoSitePlus; A8MQ27; - BioMuta; NEURL1B; - jPOST; A8MQ27; - MassIVE; A8MQ27; - PaxDb; A8MQ27; - PeptideAtlas; A8MQ27; - PRIDE; A8MQ27; - ProteomicsDB; 1935; -. [A8MQ27-1] ProteomicsDB; 7613; - ProteomicsDB; 7614; - Antibodypedia; 49674; 41 antibodies Ensembl; ENST00000369800; ENSP00000358815; ENSG00000214357. [A8MQ27-1] Ensembl; ENST00000520919; ENSP00000429797; ENSG00000214357. [A8MQ27-3] Ensembl; ENST00000522853; ENSP00000430001; ENSG00000214357. [A8MQ27-2] GeneID; 54492; - KEGG; hsa:54492; - UCSC; uc003mbt.4; human. [A8MQ27-1] CTD; 54492; - DisGeNET; 54492; - EuPathDB; HostDB:ENSG00000214357.8; - GeneCards; NEURL1B; - HGNC; HGNC:35422; NEURL1B HPA; ENSG00000214357; Low tissue specificity MIM; 615893; gene neXtProt; NX_A8MQ27; - OpenTargets; ENSG00000214357; - PharmGKB; PA164723819; - eggNOG; KOG4172; Eukaryota eggNOG; KOG4625; Eukaryota GeneTree; ENSGT00940000157079; - HOGENOM; CLU_090535_0_0_1; - InParanoid; A8MQ27; - KO; K01931; - OMA; NKNGECT; - OrthoDB; 1384219at2759; - PhylomeDB; A8MQ27; - TreeFam; TF314368; - PathwayCommons; A8MQ27; - Reactome; R-HSA-2122948; Activated NOTCH1 Transmits Signal to the Nucleus Reactome; R-HSA-2644606; Constitutive Signaling by NOTCH1 PEST Domain Mutants Reactome; R-HSA-2691232; Constitutive Signaling by NOTCH1 HD Domain Mutants Reactome; R-HSA-2894862; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Reactome; R-HSA-2979096; NOTCH2 Activation and Transmission of Signal to the Nucleus Reactome; R-HSA-9013507; NOTCH3 Activation and Transmission of Signal to the Nucleus UniPathway; UPA00143; - BioGRID-ORCS; 54492; 6 hits in 871 CRISPR screens ChiTaRS; NEURL1B; human GenomeRNAi; 54492; - Pharos; A8MQ27; Tdark PRO; PR:A8MQ27; - Proteomes; UP000005640; Chromosome 5 RNAct; A8MQ27; protein Bgee; ENSG00000214357; Expressed in layer of synovial tissue and 210 other tissues Genevisible; A8MQ27; HS GO; GO:0005769; C:early endosome; ISS:UniProtKB GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW GO; GO:0061630; F:ubiquitin protein ligase activity; ISS:UniProtKB GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW GO; GO:0070086; P:ubiquitin-dependent endocytosis; ISS:UniProtKB Gene3D; 2.60.120.920; -; 2 Gene3D; 3.30.40.10; -; 1 InterPro; IPR043136; B30.2/SPRY_sf InterPro; IPR037962; Neuralized InterPro; IPR006573; NHR_dom InterPro; IPR001841; Znf_RING InterPro; IPR013083; Znf_RING/FYVE/PHD PANTHER; PTHR12429; PTHR12429; 1 Pfam; PF07177; Neuralized; 2 SMART; SM00588; NEUZ; 2 PROSITE; PS51065; NHR; 2 PROSITE; PS50089; ZF_RING_2; 1 1: Evidence at protein level; Alternative splicing; Cytoplasm; Metal-binding; Notch signaling pathway; Phosphoprotein; Reference proteome; Repeat; Transferase; Ubl conjugation pathway; Zinc; Zinc-finger CHAIN 1..555 /note="E3 ubiquitin-protein ligase NEURL1B" /id="PRO_0000349382" DOMAIN 38..194 /note="NHR 1" /evidence="ECO:0000255|PROSITE-ProRule:PRU00400" DOMAIN 279..433 /note="NHR 2" /evidence="ECO:0000255|PROSITE-ProRule:PRU00400" ZN_FING 503..543 /note="RING-type" /evidence="ECO:0000255|PROSITE-ProRule:PRU00175" COMPBIAS 252..258 /note="Poly-Ala" COMPBIAS 437..491 /note="Ser-rich" MOD_RES 199 /note="Phosphothreonine" /evidence="ECO:0000244|PubMed:24275569" VAR_SEQ 11..192 /note="Missing (in isoform 2)" /evidence="ECO:0000303|PubMed:19723503" /id="VSP_044404" VAR_SEQ 191..430 /note="Missing (in isoform 3)" /evidence="ECO:0000303|PubMed:19723503" /id="VSP_044405" SEQUENCE 555 AA; 59270 MW; 228B459336279423 CRC64; MGNTVHRTLP DPSPPARLLA TRPCCGPGPE RRPVLGEAPR FHAQAKGKNV RLDGHSRRAT RRNSFCNGVT FTQRPIRLYE QVRLRLVAVR PGWSGALRFG FTAHDPSLMS AQDIPKYACP DLVTRPGYWA KALPENLALR DTVLAYWADR HGRVFYSVND GEPVLFHCGV AVGGPLWALI DVYGITDEVQ LLESAFADTL TPARLSQARF SACLPPSSHD AANFDNNELE NNQVVAKLGH LALGRAPGPP PADAAAAAIP CGPRERPRPA SSPALLEADL RFHATRGPDV SLSADRKVAC APRPDGGRTL VFSERPLRPG ESLFVEVGRP GLAAPGALAF GITSCDPGVL RPNELPADPD ALLDRKEYWV VARAGPVPSG GDALSFTLRP GGDVLLGING RPRGRLLCVD TTQALWAFFA VRGGVAGQLR LLGTLQSSPA TTTPSGSLSG SQDDSDSDMT FSVNQSSSAS ESSLVTAPSS PLSPPVSPVF SPPEPAGIKN GECTVCFDGE VDTVIYTCGH MCLCHSCGLR LKRQARACCP ICRRPIKDVI KIYRP
Research Areas
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References

Rullinkov, G., et al. Biochem. Biophys. Res. Commun. 389(3):420-425(2009)
Song, R., et al. J. Biol. Chem. 281(47):36391-36400(2006)
Schmutz, J., et al. Nature 431(7006):268-274(2004)

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$ 277.78
Cat# BP5404a
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