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KCTD21 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession Q4G0X4
Other Accession Q3URF8, NP_001025030.1
Additional Information
Other Names BTB/POZ domain-containing protein KCTD21, KCTD21
Target/Specificity The synthetic peptide sequence is selected from aa 247-260 of HUMAN KCTD21
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCTD21
Function Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142).
Tissue Location Highly expressed in cerebellum and brain. Expression is down-regulated in medulloblastoma EMBL; AK300320; BAG62072.1; -; mRNA EMBL; BC036058; AAH36058.1; -; mRNA CCDS; CCDS31645.1; - RefSeq; NP_001025030.1; NM_001029859.2 RefSeq; XP_005273985.1; XM_005273928.1 RefSeq; XP_006718580.1; XM_006718517.2 RefSeq; XP_006718581.1; XM_006718518.3 RefSeq; XP_011543257.1; XM_011544955.2 SMR; Q4G0X4; - BioGRID; 129500; 14 IntAct; Q4G0X4; 20 STRING; 9606.ENSP00000339340; - iPTMnet; Q4G0X4; - PhosphoSitePlus; Q4G0X4; - BioMuta; KCTD21; - DMDM; 121943921; - EPD; Q4G0X4; - jPOST; Q4G0X4; - MassIVE; Q4G0X4; - MaxQB; Q4G0X4; - PaxDb; Q4G0X4; - PeptideAtlas; Q4G0X4; - PRIDE; Q4G0X4; - ProteomicsDB; 62137; - Antibodypedia; 31300; 100 antibodies Ensembl; ENST00000340067; ENSP00000339340; ENSG00000188997 GeneID; 283219; - KEGG; hsa:283219; - UCSC; uc001ozb.4; human CTD; 283219; - DisGeNET; 283219; - EuPathDB; HostDB:ENSG00000188997.7; - GeneCards; KCTD21; - HGNC; HGNC:27452; KCTD21 HPA; ENSG00000188997; Low tissue specificity MIM; 618790; gene neXtProt; NX_Q4G0X4; - OpenTargets; ENSG00000188997; - PharmGKB; PA145148689; - eggNOG; KOG2723; Eukaryota GeneTree; ENSGT00940000160906; - HOGENOM; CLU_088122_0_0_1; - InParanoid; Q4G0X4; - KO; K21922; - OMA; QNIHFTV; - OrthoDB; 1426852at2759; - PhylomeDB; Q4G0X4; - TreeFam; TF315332; - PathwayCommons; Q4G0X4; - UniPathway; UPA00143; - BioGRID-ORCS; 283219; 7 hits in 870 CRISPR screens ChiTaRS; KCTD21; human GenomeRNAi; 283219; - Pharos; Q4G0X4; Tbio PRO; PR:Q4G0X4; - Proteomes; UP000005640; Chromosome 11 RNAct; Q4G0X4; protein Bgee; ENSG00000188997; Expressed in substantia nigra and 205 other tissues ExpressionAtlas; Q4G0X4; baseline and differential Genevisible; Q4G0X4; HS GO; GO:0097602; F:cullin family protein binding; IDA:UniProtKB GO; GO:0042826; F:histone deacetylase binding; IDA:UniProtKB GO; GO:0042802; F:identical protein binding; IPI:IntAct GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IDA:UniProtKB GO; GO:0051260; P:protein homooligomerization; IEA:InterPro GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IDA:UniProtKB InterPro; IPR000210; BTB/POZ_dom InterPro; IPR011333; SKP1/BTB/POZ_sf InterPro; IPR003131; T1-type_BTB Pfam; PF02214; BTB_2; 1 SMART; SM00225; BTB; 1 SUPFAM; SSF54695; SSF54695; 1 PROSITE; PS50097; BTB; 1 1: Evidence at protein level; Coiled coil; Growth regulation; Reference proteome; Tumor suppressor; Ubl conjugation pathway CHAIN 1..260 /note="BTB/POZ domain-containing protein KCTD21" /id="PRO_0000281151" DOMAIN 3..72 /note="BTB" /evidence="ECO:0000255|PROSITE-ProRule:PRU00037" COILED 88..112 /evidence="ECO:0000255" COMPBIAS 135..140 /note="Poly-Ser" MUTAGEN 85..87 /note="DFY->KKK: Abolishes interaction with CUL3." /evidence="ECO:0000269|PubMed:21472142" CONFLICT 152 /note="S -> P (in Ref. 1; BAG62072)" /evidence="ECO:0000305" SEQUENCE 260 AA; 29643 MW; E94BAD422C106070 CRC64; MSDPITLNVG GKLYTTSLAT LTSFPDSMLG AMFSGKMPTK RDSQGNCFID RDGKVFRYIL NFLRTSHLDL PEDFQEMGLL RREADFYQVQ PLIEALQEKE VELSKAEKNA MLNITLNQRV QTVHFTVREA PQIYSLSSSS MEVFNANIFS TSCLFLKLLG SKLFYCSNGN LSSITSHLQD PNHLTLDWVA NVEGLPEEEY TKQNLKRLWV VPANKQINSF QVFVEEVLKI ALSDGFCIDS SHPHALDFMN NKIIRLIRYR
Research Areas
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References

Gerhard, D.S., et al. Genome Res. 14 (10B), 2121-2127 (2004) :

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$ 277.78
Cat# BP5408b
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