PREPL Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q4J6C6 |
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Other Accession | NP_006027.2 |
Clone Names | 91102219 |
Gene ID | 9581 |
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Other Names | Prolyl endopeptidase-like, 3421-, Prolylendopeptidase-like, PREPL, KIAA0436 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PREPL |
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Synonyms | KIAA0436 |
Function | Serine peptidase whose precise substrate specificity remains unclear (PubMed:16143824, PubMed:16385448, PubMed:28726805). Does not cleave peptides after a arginine or lysine residue (PubMed:16143824). Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex (PubMed:23321636). May play a role in the regulation of synaptic vesicle exocytosis (PubMed:24610330). |
Cellular Location | Cytoplasm, cytosol. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q8C167}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8C167}. Golgi apparatus {ECO:0000250|UniProtKB:Q8C167}. Nucleus Note=Co-localizes with AP-1 in the trans-Golgi network (By similarity) Co-localizes with MAP2 and ACTB on the cytoskeleton (By similarity) Co-localizes with STX6 and GOSR2 at the Golgi apparatus (By similarity). {ECO:0000250|UniProtKB:Q8C167} |
Tissue Location | Expressed in pyramidal neurons of the temporal cortex and neocortex (at protein level) (PubMed:23485813). Widely expressed (PubMed:15913950, PubMed:16385448). Expressed at higher level in brain, skeletal muscle, heart and kidney (PubMed:15913950, PubMed:16385448). Expressed at the endplates in the neuromuscular junction (PubMed:24610330). |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the prolyloligopeptidase subfamily of serine peptidases. Mutations in thisgene have been associated with hypotonia-cystinuria syndrome, alsoknown as the 2p21 deletion syndrome.
References
Parvari, R., et al. Genomics 86(2):195-211(2005)Kim, D.K., et al. Biochim. Biophys. Acta 1565(1):112-121(2002)Parvari, R., et al. Am. J. Hum. Genet. 69(4):869-875(2001)Robertson, N.G., et al. Genomics 23(1):42-50(1994)
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