ZNF313 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9Y508 |
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Other Accession | NP_061153.1 |
Clone Names | 90504164 |
Gene ID | 55905 |
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Other Names | E3 ubiquitin-protein ligase RNF114, 632-, RING finger protein 114, Zinc finger protein 228, Zinc finger protein 313, RNF114, ZNF228, ZNF313 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | RNF114 |
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Synonyms | ZNF228, ZNF313 |
Function | E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates (PubMed:23645206, PubMed:25165885). In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity (PubMed:25165885, PubMed:28708287). Acts as a negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3 (PubMed:25165885). May promote the ubiquitination of TRAF6 as well (PubMed:28708287). Acts also as a negative regulator of T-cell activation (PubMed:25165885). Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation (PubMed:25165885). Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C (PubMed:23645206). This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis. |
Cellular Location | Cytoplasm. Nucleus |
Tissue Location | Expressed in numerous tissues, including skin, CD4 lymphocytes and dendritic cells. Highest levels in testis |
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Provided below are standard protocols that you may find useful for product applications.
Background
ZNF313 is a novel human zinc finger protein gene that contains both ring finger and C(2)H(2) domain. It may play a role in spermatogenesis.
References
Capon, F., et al. Hum. Mol. Genet. 17(13):1938-1945(2008)Ma, Y.X., et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 35(3):230-237(2003)Deloukas, P., et al. Nature 414(6866):865-871(2001)Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
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