SHFM3 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P57775 |
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Other Accession | NP_071322 |
Clone Names | 2082306 |
Gene ID | 6468 |
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Other Names | F-box/WD repeat-containing protein 4, Dactylin, F-box and WD-40 domain-containing protein 4, FBXW4, FBW4, SHFM3 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6262a was selected from the C-term region of human SHFM3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | FBXW4 |
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Synonyms | FBW4, SHFM3 |
Function | Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling. |
Tissue Location | Expressed in brain, kidney, lung and liver. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22.
References
de Mollerat, X.J., et al., Hum. Mol. Genet. 12(16):1959-1971 (2003).Ilyin, G.P., et al., Genomics 67(1):40-47 (2000).Sidow, A., et al., Nat. Genet. 23(1):104-107 (1999).Ianakiev, P., et al., Biochem. Biophys. Res. Commun. 261(1):64-70 (1999).Gurrieri, F., et al., Am. J. Med. Genet. 62(4):427-436 (1996).
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