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VEGFD (VEGF4) Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O43915 |
|---|
| Gene ID | 2277 |
|---|---|
| Other Names | Vascular endothelial growth factor D, VEGF-D, c-Fos-induced growth factor, FIGF, FIGF, VEGFD |
| Target/Specificity | The synthetic peptide sequence is selected from aa 337-352 of HUMAN FIGF |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | VEGFD (HGNC:3708) |
|---|---|
| Synonyms | FIGF |
| Function | Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. |
| Cellular Location | Secreted. |
| Tissue Location | Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C.
References
Orlandini, M., et al., J. Biol. Chem. 278(45):44650-44656 (2003).
McColl, B.K., et al., J. Exp. Med. 198(6):863-868 (2003).
Rissanen, T.T., et al., Circ. Res. 92(10):1098-1106 (2003).
Nakamura, Y., et al., Clin. Cancer Res. 9(2):716-721 (2003).
Yokoyama, Y., et al., Br. J. Cancer 88(2):237-244 (2003).
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